Abstract: Objective Tinidazole had been taken as model drug to compare the diffrence of percutaneous absorption and deposit effect between BALB/c nude mice and SD rats. Methods Percutaneous absorption experiment was performed with a osmosis device in vitro.then detect the osmosis dose and deposit effect in different time. Results The study on percutaneous absorption and deposit effect showed BALB/c nude mice could increase the penetration rate of Tinidzole than SD rats(P<0.01). Conclusion BALB/c nude mice is more suitable for experiment of extrinsic percutaneous absorption than SD rats.

Key words: Tinidazole, Azone, BALB/c nude mice, SD rats, Percutaneous absorption, Deposit effect

摘要： 目的以替硝唑为模型药物,比较其经BALB/c裸小鼠和SD大鼠透皮吸收及贮库效应的差异。方法在离体透皮吸收实验装置上,测定不同时间替硝唑经两种皮肤的透过量,并测定各自的贮库效应。结果透皮吸收和贮库效应的研究表明,BALB/c裸小鼠对替硝唑的透皮速率比SD大鼠显著增加(P<0.01)。结论BALB/c裸小鼠比SD大鼠更适合用于体外透皮吸收试验。

关键词: 替硝唑, 氮酮, BALB/c裸小鼠, SD大鼠, 透皮吸收, 贮库效应