Abstract: Objective To set up the animal model of type 2 mellitus diabetes in SD rats.MethodsSD rats were fed with a diet enriched in fat and fructose for 4 weeks to induce insulin resistance,and the rats were injected intraperitoneally with a low_dose streptozocin(STZ) once(30mg/kg) to induce hyperglycemia after 2 weeks.ResultsInsulin sensitivity index decreased significantly of experimental group and hypertension was seen after rats fed with a diet enriched in fat and fructose.There were hyperglycemia,increased blood insulin and lower insulin sensitivity in rat models after STZ injection.ConclusionThe experiment provides an ideal model of type 2 mellitus diabetes with SD rats.

Key words: Diabetes Mellitus, Streptozocin, Fructose, Rats

摘要： 目的建立SD大鼠2型糖尿病模型。方法选SD大鼠,先喂以高脂高果糖饲料4周,导致胰岛素抵抗,继以小剂量链脲佐菌素(STZ)(30mg/kg)腹腔注射1次,2周后诱导建立2型糖尿病模型。结果高糖高脂饮食后4周,大鼠出现胰岛素抵抗和高脂血症。注射STZ后,大鼠血糖、血胰岛素升高,胰岛素敏感性下降。结论本实验为糖尿病的实验研究提供了一种理想的动物模型。

关键词: 糖尿病, 链脲佐菌素, 果糖, 大鼠