Abstract: Objective To observe the anesthetic effect of Su Mian Xin Ⅱ on experimental white miniature pigs.Methods30 adult white miniature pigs were randomly divided into group A,group B,and group C.Simple anaesthesia was performed by intramuscular injection of Su Mian Xin Ⅱ in group A,and combined anaesthesia was performed in group B and group C by intramuscular injections of Su Mian Xin Ⅱ and sodium pentobarbital based on different dosage proportion of the two drugs.The induction period of anaesthesia,maintain duration of anaesthesia,and analepsia period,and temperature,breathing rate,and heart rate during anaesthesia were observed and recorded in the three groups.ResultsIn group A,B,and C,the induction period of anaesthesia was 11.4±7.85 min,5.7±2.51 min,and 4.7±2.83 min respectively,maintain duration of anaesthesia was 122.7±42.82 min,104.4±27.68 min,and 122.8±19.59 min respectively,and analepsia period was 47.8±46.04 min,85.9±92.64,and 102.1±59.62 min respectively.The temperature of all the pigs from the three groups has been trending down from injection of the drug to analepsia.The breathing rate of all the pigs from the three groups has been trending upwards from 10 min to 90 min after injection of the drug,and then was decreased slightly during analepsia period.Heart rate of all the pigs from the three groups was gradually decreased from injection of the drug to analepsia.Conclusion Experimental white miniature pig may possess a stronger toleration to Su Mian Xin Ⅱ,and single application of Su Mian Xin Ⅱ or combined application of it and sodium pentobarbital could achieve more satisfactory anesthesia effect.

Key words: Su-Mian-Xin Ⅱ, Application of Su-Mian-XinⅡ comoounded with sodium pentobarbital, Experimental miniature pigs, Anesthesia

摘要： 目的观察速眠新Ⅱ对实验用白香猪的麻醉效果。方法将30头成年实验用白香猪随机分为三个组,A组为速眠新Ⅱ组,B组和C组为速眠新Ⅱ和戊巴比妥钠不同比例复合麻醉组。观察诱导期、维持期、苏醒期,监测动物体温、呼吸频率和心率。结果A、B、C三个组的诱导期分别为(11.4±7.85)min(、122.7±42.82)min和(47.8±46.04)min;维持期(5.7±2.51)min(、104.4±27.68)min和(85.9±92.64)min;苏醒期分别为(4.7±2.83)min(、122.8±19.5)min和(102.1±59.62)min。三组动物体温从给药开始至苏醒在总体上均呈下降趋势;三组动物的呼吸频率均表现为给药后10 min至90 min缓慢升高、在苏醒期略下降的规律性变化;三组动物心率从给药开始至苏醒均在持续下降。结论实验用白香猪对速眠新Ⅱ的耐受高,单纯使用速眠新Ⅱ和与戊巴比妥钠复合使用能获得满意的麻醉深度。

关键词: 速眠新Ⅱ, 速眠新Ⅱ与戊巴比妥钠联用, 实验用白香猪, 麻醉