Abstract: To set up a animal model of cleft alveolus by surgical approach. Methods The alveolus model was made surgically in 20 minipig.Two "L" mucoperiosteal flaps were designed at both labial and palatal sides.A segmental bone,about 8 mm×9 mm,from the first lateral medial tooth to the medial of the canine was excised.The raw bony surface was covered by the mucoperiosteal flaps.The samples were examined by gross radiation,histological analysis.Results In all experimental minipig,hard tissue was not closed up and soft tissue was healed up.Conclusion The animal alveolar cleft model by surgical technique on Guizhou minipig was set up.

Key words: Alveolar cleft, Animal model, Guizhou minipig

摘要： 目的采用外科手术方法建立贵州小型猪牙槽嵴裂动物模型,为牙槽嵴裂的相关治疗提供实验基础。方法贵州小型猪20只。设计唇腭侧两个"L"型黏骨膜瓣,去除自第一乳侧切牙近中至乳尖牙近中约8 mm×9 mm骨质;将唇腭侧黏膜覆盖骨创面严密缝合。术后通过大体观察、X线、组织学检查评价实验结果。结果术后观察10周,所有实验动物所形成的牙槽嵴裂裂隙保持良好,无自愈;软组织愈合良好。结论利用贵州小型猪建立的人工牙槽嵴裂动物模型方法可靠,稳定性好。

关键词: 牙槽嵴, 动物模型, 贵州小型猪