Abstract: Objective To evaluate the effects of the Sufeirunchang Decoction on rat drug dependence constipation.Methods 30 Clean level SD rats were divided randomly into the normal control group(n=10),model group(n=10)and treatment group(n=10).Beside the control group,each group by limiting water but limitless diet contributes to cause the constipation.It is repeatedly treated by infusing stomach with rhubarb so as to cause medicine dependent constipation.The normal control group rats are filled the stomach with the distilled water.Treatment group tats are filled stomach with Sufeirunchang Decoction for observing the effect of Sufeirunchang Decoction to this disease model.Observation target:Excrement displacement /unit time,First grain of bowel movement discharges time,Barium sulfate advance rate in small intestine.The article compared the effect of Sufeirunchang Decoction around treatment with above targets.Results(1)each model group is worse than the normal control grouping ordinary circumstances excrement displacement is fewer and the nature is harder;intestinal tract transmission function is slow-down.The difference is significant(P<0.05).(2)The control group rats have not any abnormal performance.(3)The ordinary circumstances of model group rats is good after feeding the medicine;intestinal tract transmission function is close to normal control group;the difference is not significant(P>0.05).Conclusion The Sufeirunchang Decoction may improve the function of gastro-intestinal tract of rats;recover drug dependent constipation and promote stomach and intestines creeping motion.

Key words: The Sufeirunchang Decoction, Rats, Drug dependence constipation

摘要： 目的探讨中药复方肃肺润肠汤对大鼠药物依赖性便秘的影响。方法清洁级SD大鼠30只,随机分为对照组(n=10)、模型组(n=10)和治疗组(n=10)。除对照组外,模型及治疗组用限水不禁食的方法造成大鼠便秘,继给各组大鼠用大黄行灌胃治疗,如此反复多次,使大鼠形成药物依赖性便秘,在此基础上,大鼠治疗组给予肃肺润肠汤灌胃,以观察该中药复方对该疾病模型大鼠的作用。肠道传输功能的观察指标:单位时间粪便排出量、首粒大便排出时间、硫酸钡小肠推进率;并用上述观察指标进行给中药复方前后的比较。对照组给予蒸馏水灌胃。结果⑴模型组比对照组单位时间粪便排出量少、质硬,肠道的传输功能减慢,差异有显著性(P<0.05);⑵对照组大鼠则无任何特殊表现;⑶治疗组经喂药治疗后一般情况较好,肠道的传输功能接近对照组,差异无显著性(P>0.05)。结论肃肺润肠汤可以促进胃肠蠕动,改善药物依赖性便秘大鼠肠道的传输功能。

关键词: 肃肺润肠汤, 大鼠, 药物依赖性便秘