Study on the Parameters of Main Internal Organs in SPF Male SD Rats at Different Ages

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Study on the Parameters of Main Internal Organs in SPF Male SD Rats at Different Ages

WANG Yao 1,2 , TANG Da-xuan1, GE Lin, XIONG Jing-yue1, WANG Li 1,2 , LIANG Ya-jun 1,2 , MOU Dao-hua 1,2 , TAN Zheng-huai 1

(1. Key Laboratory of Biological Evaluation of TCM Quality of SATCM, Institute of Pharmacology and Toxicology of Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China)(2. Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China

Received:2010-02-28 Revised:2010-02-28 Online:2010-02-28 Published:2010-02-28

不同月龄SPF级SD雄性大鼠主要脏器参数的测定

王尧;唐大轩;葛麟;熊静悦;王莉;梁娅君;牟道华;谭正怀;

四川省中医药科学院药理毒理研究所国家中医药管理局中药质量生物学评价重点研究室;成都中医药大学;

Abstract

Abstract: Objective To investigate the normal values of body weight, indexes and weight of main internal organs in male Sprague Dawley (SD) rats at different ages.Methods Weight of body and ten internal organs of male SD rats were measured monthly from 2 to 8 month-old, and the indexes of each organ were calculated simultaneously. Results From two-month to eight-month old, the weight of heart, liver, kidney, brain, epididymis and adrenal gland increased, but decreased in thymus gland. Meanwhile the indexes of heart, liver, spleen, lung, brain, thymus gland and adrenal gland reduced gradually as the body weight increased.Conclusion In SPF male SD rats, the weight and indexes of the main internal organs can reflect their structure changes and physiological functions.

Key words: SPF male SD rat, Body weight, Weight of internal organs, Organ index

摘要： 目的提供SPF级SD雄性大鼠的体重、脏器重量及脏器指数的正常值范围。方法选用1月龄的SPF级雄性SD大鼠75只,分别于2月、3月、4月、7月和8月时测定其体重及10个主要脏器重量,并计算脏器指数。结果在2月龄至8月龄,雄性SD大鼠的心、肝、肺、肾、脑、肾上腺及附睾等脏器的重量均逐渐增长,而胸腺重量却逐渐降低。然而随着体重等因素的变化,心、肝、脾、肺、肾、脑及肾上腺等指数均逐渐降低。结论SPF级SD雄性大鼠体重增长、主要脏器重量及其指数与其脏器结构变化以及机体正常生理功能状态密切相关。

关键词: SD雄性大鼠, 体重, 脏器重量, 脏器指数

WANG Yao 1,2 , TANG Da-xuan1, GE Lin, XIONG Jing-yue1, WANG Li 1,2 , LIANG Ya-jun 1,2 , MOU Dao-hua 1,2 , TAN Zheng-huai 1. Study on the Parameters of Main Internal Organs in SPF Male SD Rats at Different Ages[J]. laboratory animal science.

王尧;唐大轩;葛麟;熊静悦;王莉;梁娅君;牟道华;谭正怀;. 不同月龄SPF级SD雄性大鼠主要脏器参数的测定[J]. 实验动物科学.

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