Abstract: Objective　To observe the effect of Simplified Chaihu Shugan Powder(SCSP) on behaviors of depression-pain comorbidities rats.Methods　Thirty-two SPF male SD rats were randomly divided into control group, model group, fluoxetine group, SCSP group, with each group consisting of 8 rats. Each drug group was made by intraperitoneal injection of reserpine, fluoxetine hydrochloride was used as the positive control drug, and each drug group was given the corresponding drug by intragastric administration for 14 days.At the end of the experiment, we measured the body weight, we use forced swimming test, sucrose preference test,open field test to evaluate the depressive status. We use thermal withdrawal latency(TWL)and paw withdrawal thresholds(PWT)to evaluate the pain sensation.Results　Compared with the control group, the body weight,body weight gain,sugar water preference index,total distance and numbers of crossing grids of open field experiment in model group decreased significantly (P<0.01); immobile time of forced swimming test in model group increased significantly (P<0.01);the foot retraction time of TWL, foot retraction threshold of PWT decreased significantly (P<0.01) in model group. Compared with the model group, the body weight,body weight gain,total distance and numbers of crossing grids of open field experiment in SCSP group increased significantly (P<0.01); sugar water preference index increased in SCSP group (P<0.05);immobile time of forced swimming test in SCSP group decreased significantly (P<0.01);the foot retraction time of TWL, foot retraction threshold of PWT increased significantly (P<0.01) in SCSP group.Conclusion　SCSP can effectively increase the body weight gain of depression-pain comorbidities rats, partially combat the behavioral changes caused by reserpine, improve despair, loss of pleasure, decreased exercise ability and pain of depression-pain comorbiditis rats, and achieve the effect of relieving depression and pain.

Key words: simplified Chaihu-Shugan powder, depression-pain comorbidities, behaviors

摘要： 目的　观察柴胡疏肝散精简方对抑郁疼痛共病大鼠行为学的影响。方法　将32只SPF级SD雄性大鼠随机 分为空白组、模型组、氟西汀组和精简方组,每组8只,以腹腔注射利血平造模,以盐酸氟西汀为阳性对照药,各药 物组灌胃相应药物,连续14 d。测量大鼠体质量,以强迫游泳实验、糖水偏好实验和旷场实验评估抑郁状态,以热 痛缩足潜伏期、机械性撤足阈值评估疼痛感觉。结果　与空白组比较,模型组体质量和体质量增量明显降低(P< 0.01);强迫游泳实验不动时间明显增加(P<0.01)、糖水偏好指数明显降低(P<0.01)、旷场实验运动总距离及穿 格数明显减少(P<0.01);热痛实验的缩足时间明显降低 (P<0.01); 机械痛实验的撤足阈值明显降低(P<0.01)。 与模型组比较,精简方组体质量和体质量增量明显增加(P<0.01);强迫游泳实验不动时间明显减少(P<0.01)、糖 水偏好指数增加(P<0.05)、旷场实验运动总距离及穿格数明显增加(P<0.01);热痛实验的缩足时间明显增加(P< 0.01); 机械痛实验的撤足阈值明显增加(P<0.01)。结论　柴胡疏肝散精简方能有效增加抑郁疼痛共病大鼠体质 量,部分对抗利血平引起的行为学改变,改善抑郁疼痛共病大鼠绝望、快感丧失、运动能力下降及疼痛,达到解郁止 痛的功效。

关键词: 柴胡疏肝散精简方, 抑郁疼痛共病, 行为学