Abstract:

Because of its unique gene delivery characteristics and targeting specificity, viral vector has

become a more and more important tool for transporting nucleic acids to various experimental systems. It

also plays an important role in the fields of gene therapy and disease prevention and control, providing a

new approach to address both inherited and acquired diseases. The viral vector delivers therapeutic gene

material and its associated regulatory elements into the nucleus and attempts to cure disease or improve

body’ s ability to fight disease by modifying the patient’ s cells genetically, improving the health of the

patients. The use of viral vector for disease prevention and scientific research requires understanding the

characteristics of viral vectors, assessing human health and environmental risks, and further stresses the

importance of biosafety governance. In this article, we introduced the characteristics of commonly used

viral vector systems, some of the biosafety challenges and the biological and environmental risk

assessment,providing reference for the research / clinical application of viral vector systems in China.

Key words:

viral vector, biosafety, risk assessment

摘要：

通过介绍常用病毒载体的特点、病毒载体系统运用的生物安全挑战及载体系统的生物和环境风险评估,为我

国病毒载体系统研发及临床运用等方面提供参考依据。 病毒载体系统将治疗性基因及其相关的调控元件传递到

人类细胞核中,通过基因改造患者的细胞,从而治愈疾病或提高身体抵抗疾病的能力,改善患者的健康状况。 病毒

载体因其独特的基因传递特征和靶向特异性,已越来越成为向各种实验系统转运核酸的重要工具。 病毒载体还在

基因治疗和疾病防控等领域起着重要的作用,为解决人类遗传和获得性疾病提供了一种新的解决方法。 利用病毒

载体系统进行疾病防控及科学研究,需要了解病毒载体的特性、进行人类健康和环境风险等评估,且强调生物安全

管理的重要性。

关键词:

病毒载体, 生物安全, 风险评估

CLC Number: 

• Q95-3