Abstract: Objective Existing studies have shown that hypoxia affects mammalian brain function. In this
paper, Morris water maze experiment was employed to analyze the effects of intermittent hypoxia on
learning and memory ability of lactation. Method The retrieval time was limited to February 25, 2023
through the databases of CNKI, VIP database, WANFANG data, Web of Science, PubMed and
Elsevier. RevMan 5. 3 software was used for statistical analysis of the extracted data, Then sensitivity
analysis was used to evaluate the quality of the included studies. Result A total of 24 articles and 263
subjects were included in this study. In the Morris Water Maze experiments, the escape latency of rats/
mice was increased after treated with intermittent hypoxia for two weeks compared with the control group
[ SMD = 4. 17, 95%CI (3. 46, 4. 89) , P<0. 01] . The time of rats/ mice crossing the target quadrant was
decreased [ SMD = - 3. 07, 95% CI ( - 3. 56, - 2. 58 ) , P < 0. 01 ] . After treatment with intermittent
hypoxia for four weeks, the escape latency increased [ SMD = 8. 03, 95%CI (6. 21, 10. 40) , P<0. 01] ;
The time across the target quadrant shortened [ SMD = - 6. 79, 95% CI ( - 8. 60, - 4. 99) , P < 0. 01] .Conclusion Treated with intermittent hypoxia, the escape latency of rats/ mice in the water maze rises,
and the time of cross the target quadrant is shortened, indicating the learning and memory ability of mice /
rats is impaired.

Key words: intermittent hypoxia, Meta-analysis, Morris water maze

摘要： 目的 本文针对现有 Morris 水迷宫实验结果进行分析,探讨间歇低氧对哺乳动物学习记忆能力的影响。
方法 通过检索中国知网(CNKI) 、维普、万方、Web of Science、PubMed、Elsevier 等数据库,根据纳入及排除标准筛
选文献,检索时间限定为建库到 2023 年 2 月 25 日。 使用 RevMan 5. 3 软件对提取的数据进行统计学分析,主要分
析间歇低氧对鼠在 Morris 水迷宫实验中逃避潜伏期和跨越目标象限时间的影响。 随后采用敏感性分析的方法对
所纳入研究的质量进行评价。 结果 本研究共纳入 24 篇文章,263 个研究对象。 Meta 分析结果显示,在 Morris 水
迷宫实验中,相较于对照组,在间歇低氧 2 周后鼠逃避潜伏期增长[ SMD = 4. 17,95% CI( 3. 46,4. 89) ,P< 0. 01] ;而
鼠跨越目标象限时间缩短[ SMD = -3. 07,95%CI( -3. 56,-2. 58) ,P<0. 01] 。 在间歇低氧 4 周后鼠逃避潜伏期长于
对照组 [ SMD = 8. 03, 95% CI ( 6. 21, 10. 40) , P < 0. 01] ; 跨 越 目 标 象 限 时 间 缩 短 [ SMD = - 6. 79, 95% CI ( - 8. 60,
-4. 99) ,P<0. 01] 。 结论 在间歇低氧不同时间后,鼠在水迷宫中的逃避潜伏期增长;而跨越目标象限时间缩短,
即表现出学习记忆能力受损。

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