Abstract: Dietary factors are the most important environmental factors leading to the occurrence of non-alcoholic fatty liver disease. The non-alcoholic fatty liver model induced by high-fat diet has the characteristics of being close to the clinical and stable model, so it is widely used in non-alcoholic fatty liver research. This article briefly introduced the model of fatty liver in rats commonly used in the non-alcoholic fatty liver inducing model, and discussed the technical points and experience of the non-alcoholic fatty liver model induced by high-fat diet.

Key words: high-fat diet, non-alcoholic fatty liver disease, rat model

摘要： 饮食因素是导致非酒精性脂肪肝发生的最主要的环境因素。高脂饮食诱导非酒精性脂肪肝大鼠模型具有贴近临床、模型稳定的特点，故被广泛运用于非酒精性脂肪肝的研究中。本文简要介绍了非酒精性脂肪肝诱导模型中常用的大鼠脂肪肝模型，并探讨了制作高脂饮食诱导大鼠非酒精性脂肪肝模型的技术要点及体会。

关键词: 高脂饮食, 非酒精性脂肪肝, 大鼠模型