Abstract: Abstract: Objective To observe the effects of Polygonatum sibiricum polysaccharides( PSP) on myocardial injury and the possible mechanism in acute myocardial infarction rats． Method The AMI models were established by closing the left anterior descending coronary artery with SD rats，sham group wearing without ligation，then the successful model rats were randomly divided into model group，PSP high，medium and low dose group ( 900 mg· kg － 1、450 mg·kg － 1、225 mg·kg － 1 ) ，positive group ( Shexiang protect myocardial pills，12. 2 mg·kg － 1 ) ． 10 rats in each group． Gastric infusion one time every day for 28 days． ECG S-T were measured before surgery and immediately after surgery，1，3，7，10，14，21，28 d in each group; the concentration serum inflammatory cytokines IL-6，TNF-α，and GSH-Px，MDA levels were measured by ELISA，myocardium tissue morphology was measured by the microscope． Ｒesult Compared with model group，PSP inhibited ST segment rat model of myocardial infarction; decreased serum levels of TNF-α， IL-6，MDA( p ＜ 0. 05 or 0. 01) ，increased serum levels of GSH-Px( p ＜ 0. 05 or 0. 01) ，myocardial tissue morphology was improved． Conclusion PSP could improve the myocardial injury in acute myocardial infarction rats，its mechanism may be related to alleviate inflammation， improve the oxygen radical scavenging ability，reduce lipid peroxidation damage．

Key words: <p>PSP, cute myocardial infarction, inflammation, oxidative stress</p>

摘要： 摘要: 目的探讨黄精多糖( PSP) 对急性心肌梗死模型( AMI) 大鼠损伤的保护作用及可能机制。方法采用结扎冠状动脉左前降支的方法制备心肌梗死动物模型，假手术组只穿线不结扎，将造模成功的大鼠随机分为模型组、黄精多糖高、中、低剂量组( 900 mg /kg、450 mg /kg、225 mg /kg) 及阳性组( 麝香保心丸， 12. 2 mg /kg·d) ，每组10 只，每日灌胃1 次，连续4 周。分别记录造模前、造模即刻及给药1、3、7、10、14、21、28 d 心电图S-T 段变化，采用酶联免疫吸附法( ELISA) 测定各组大鼠血清中肿瘤坏死因子α( TNF-α) 、白介素6( IL-6) 、谷胱甘肽过氧化物酶( GSH-Px) 及丙二醛( MDA) 含量; 显微镜下观察受损心肌病理学的改变。结果与模型组相比，黄精多糖能明显抑制心肌梗死模型大鼠S-T 段的升高; 各给药组大鼠血清IL-6、TNF-α 水平均显著降低( P ＜ 0. 05 或0. 01) ，GSH-Px 活性升高( P ＜ 0. 05或0. 01) ，并降低MDA 含量( P ＜ 0. 05 或0. 01) ，心肌损伤程度明显改善。结论PSP 对急性心肌梗死模型大鼠心肌损伤有保护作用，其作用机制可能与减轻炎症反应，提高氧自由基清除能力，减少脂质过氧化损伤有关。

关键词: <, p>, 黄精多糖, 急性心肌梗死, 炎症, 氧化应激<, /p>