Abstract: Abstract: Objective To determine blood and organ coefficient values between C57 mice and MＲL / lpr transgenic mice at the ages of 4 months，5 months and 6 months old． Method We used MEK － 7222K automatic blood analyzer to analyze C57 mice and MＲL / lpr transgenic mice blood values． Ｒesult On the blood detection，the percentage of neutrophils ( NE%) ， red blood cell count ( ＲBC ) ， hematocrit ( HCT ) ，mean corpuscular hemoglobin ( MCH) ，red blood cells mean corpuscular hemoglobin concentration ( MCHC) values in different months between C57 mice and MＲL / lpr transgenic mice were significantly different ( P ＜ 0. 01) ; among nine items there was no significant difference compared ( P ＞ 0. 05) ． On organ coefficient aspects，C57 mice coefficient heart，kidneys coefficient is significantly higher than the same month-old MＲL / lpr transgenic mice ( P ＜ 0. 01) ; MＲL / lpr transgenic mouse liver coefficient is significantly higher than the same month-old C57 mice ( P ＜ 0. 01) ;there was no significant difference ( P ＞ 0. 05) on other comparable projects． Conclusion Partial blood and organ coefficient data were significantly different in the same months of C57 mice and MＲL / lpr transgenic mice．

Key words: systemic lupus erythematosus, MRL / lpr transgenic mice, blood, organ coefficient

摘要： 摘要: 目的测定C57 小鼠与MＲL/lpr 转基因小鼠在4 月龄、5 月龄和6 月龄的血常规值和脏器系数。方法用MEK － 7222K 全自动血液分析仪检测C57 小鼠与MＲL/lpr 转基因小鼠血常规值。结果血常规检测方面，C57 小鼠与MＲL/lpr 转基因小鼠相比，中性粒细胞百分率( NE%) 、红细胞计数( ＲBC) 、红细胞压积( HCT) 、红细胞平均血红蛋白( MCH) 、红细胞平均血红蛋白浓度( MCHC) 在不同月龄的数值差异极显著( P ＜ 0. 01) ; 其中9 个检测比较项目差异不显著( P ＞ 0. 05) 。脏器系数方面，C57 小鼠的心脏系数、肾脏系数显著高于同月龄的MＲL/lpr 转基因小鼠( P ＜ 0. 01) ; MＲL/lpr 转基因小鼠的肝脏系数显著高于同月龄的C57 小鼠( P ＜ 0. 01) ; 其他比较项目差异不显著( P ＞ 0. 05) 。结论C57 小鼠与MＲL/lpr 转基因小鼠在同月龄的部分血常规数据和脏器系数差异显著。

关键词: 系统性红斑狼疮, MRL/lpr 转基因小鼠, 血常规, 脏器系数