Abstract: Abstract: Laboratory animal become more and more important in various fields with the development of science and technology． In October 2012，our lab took laboratory rodents from Beijing area to investigate the health status of laboratory rodents． Their heart，liver，spleen，lung，kidney，large intestine and small intestine were sampled，and then prepared into two different sections for optical microscopy including all paraffin specimens stained with HE and the frozen sections stained with Oil Red O and PAS． The results showed that the vast majority of laboratory mice were pathologically diagnosed as healthy animals． Liver fatty degeneration and slight lung lesion were main lesions， which might affect the health of laboratory animals． Protein cast of kidney，fibrin exudation occured in the Bowman's capsule and parasitic infections in the large intestine could be seen in several individuals． The result might be related to breeding，feeding environment and transport stress．

Key words: laboratory rodents, pathological diagnosis, organ diseases

摘要： 摘要: 随着现代科技的发展，实验动物在多方面起着越来越重要的作用。2012 年10 月，本实验室参与了北京市实 验动物管理办公室组织的北京市啮齿类实验动物健康状况调查。采集心、肝、脾、肺、肾、大肠和小肠进行组织病理 学观察，通过石蜡切片HE 染色、冰冻切片油红O 染色、PAS 染色等方法对啮齿类实验动物的健康状况进行鉴定。 结果显示，部分动物肝脏表现出不同程度的肝细胞肿胀、轻度肺脏病变，少数表现出肾脏管型、肾小囊腔蛋白样物 质渗出和大肠寄生虫感染，但是啮齿类实验动物总体水平属健康状况。以上病变的出现可能与动物的生存环境、 饲料营养成分和运输处死过程中的应激有关。

关键词: 啮齿类实验动物, 病理学诊断, 脏器病变