Abstract: Abstract: Objective To explore the relativity between the rotational behavior of Parkinsons disease mice model and the spontaneous rotational behavior to the same direction in senescence accelerated mouse SAM-P /8． MethodsThe mice were divided into 2 groups : 1． Rotation group includes 6 Male SAM-P /8 at 7-month old that appear rotational behaviors2． Normal control group includes 6 Male SAM-R /1 at 7-month ． First applies “the scores of aging”to study the aging symptoms; then evaluate their characteristics of behavior of rotation to the same direction by PD mice model standard． Results Compared with SAM-R /1 control group，SAM-P /8 group appeared obvious aging sign and symptoms at 7 months old; SAM-P /8 appear steady rotational behavior to the same direction，the frequency is 60 rotations per minute． This kind of rotation behavior coincides with PD mice model standard． Conclusions Senescence accelerated mouse SAM-P /8 appears syndrome similar to PD． This discovery will make sense to the research of PD．

Key words: mouse, SAM-P /8, rotation to the same direction, Parkinson

摘要： 摘要: 目的探讨快速老化小鼠SAM-P /8 的同向旋转现象与帕金森病动物模型的相关性。方法取发作旋转行为 的7 月龄雄性SAM-P /8 和同源对照SAM-R /1 小鼠各6 只，分为旋转组和正常对照组两组，首先采用老化度评价标 准对其老化度进行评定，其次根据帕金森病动物模型造模标准对其旋转行为进行评定。结果同月龄SAM-P /8 的 老化度高于SAM-R /1; SAM-P /8 出现可重复的同向右侧旋转，频率为60 r /min，符合帕金森病动物模型造模成功的 标准，SAM-R /1 无旋转现象出现。结论初步认定SAM-P /8 的同向旋转现象为类帕金森病现象，对帕金森病研究 有重要意义。

关键词: SAM-P /8 小鼠, 同向旋转, 帕金森病