Abstract: Objective To investigate the effects of organ chlorine pesticide--endosulfan--on the blood cell immune factors in Mongolian gerbil we designed this experiment．Methods 50 Mongolian gerbils were randomly divided into 5 groups．They were garaged endosulfan at levels of 0，0．4，0．8，1．6，and 6．4 ms／(kg·d)， respectively．twenty one days later，blood was then collected to determine 3 of blood cell immune factors．Results (1)The expression levels of CD59 on erythrocyte membrane and CD35 on B lymphocyte membrane had no differences among the 5 groups(P>0．05)after treatment；(2)The levels of CD58 on erythrocyte membrane gradually decreased with the increase of endosulfan dosage，and the three groups given endosulfan level at 0．8，1．6，6．4mg／(kg·d)were significantly lower than that of the control group(P<0．05)．Conclusion rI'IIe results suggested that endosulfan can inhibit the express of CD58 on erythrocyte，but have no effect on the expression levels of CD59 on erythrocyte membrane and CD35 on B lymphocyte membrane．

Key words: Endosulfan, Mongolian gerbil, CD35, CD58, CD59

摘要： 目的探讨有机氯农药硫丹对长爪沙鼠血细胞免疫功能相关因子的影响。方法将50只长爪沙鼠随机分 喊5组，各组动物所用硫丹灌胃的剂量依次为：O mr,／(kg·d)、0．4 me／(kg·d)、0．8 ms／(k8·d)、1．6 me／(kg·d)和 6．4 mg／(kg·d)。灌胃21 d后，取血检测血细胞免疫功能相关因子的表达。结果药物处理后。红细胞表面CD59 因子和B淋巴细胞表面CD35因子的表达量在各实验组和对照组间没有明显差异(P>0．05)。红细胞膜表面 CD58因子随硫丹浓度的升高显著下降，0．8 mg／(kg·d)、1．6 me／(kg·d)和6．4 me／(kg·d)组较对照组有显著降低 (P<0．05)。结论硫丹能抑制长爪沙鼠红细胞膜表面CD58因子表达。但对红细胞膜表面CD59和B细胞表面的 CD35的表达没有影响。

关键词: 硫丹, 长爪沙鼠, CD35, CD58, CD59