Abstract: Microtus fortis is one of the wildlife resources in China and can be expected to be a latency laboratory animal in biomedical research. The paper is summary of a series of studies including ecology, zoology, pathology, genetics, immunology and molecule biology for Microtus fortis during the past five years since 1998 Not only approved the trait of natural resistance in Microtus fortis to Schistosoma japonicum, This paper explored its mechanism of the natural resistance trait, but also researched on bred the closed colony of Microtus fortis in our laboratory and the possible primary method in genetic monitors. The authors analyzed and compared the diffence between M.f fortis and M.f.calamorum by the method of phylogenetic tree. The results showed that they belonged to two groups of DNA genome. In addition, it had been found that the animal's new pathological characters will be explored the other field in biomedical research work. The paper also discussed the theoretical strategies on breeding wildlife as laboratory animal and protecting wildlife resources of germplasm.

Key words: Microtus fortis, Laboratory Animal, Germ Plasm

摘要： 东方田鼠是我国具有潜在应用价值的野生动物资源 ,我们从 1998年开始经历五年对它从生态学、动物学、病理学、遗传学、免疫学、分子生物学等方面进行的系列研究。不但进一步证实了它的抗日本血吸虫生物学特性 ,而且初步探讨了抗日本血吸虫的机理 ,成功地培育了封闭群东方田鼠 ,摸索了对它进行遗传监测的可能方法 ,对东方田鼠长江亚种和宁夏指名亚种基因组采用系统发育树分析方法 ,分析和比较了两个亚种的亲缘关系 ,显示它们的基因组DNA明显分为两大组别 ;此外 ,发现了新的病理生物学特征 ,开拓了应用领域。本文还从理论上论述了野生动物实验动物化和种质资源保护的研究策略 ,为今后工作提出了方向

关键词: 东方田鼠, 实验动物化, 种质