Abstract: The development of organoid has a history of over 100 years. With the proposed concept of organoids-on-ohips(OOC) , it is possible to construct the microphysiological system of human organs on chip. Organoid technology is expected to be the most potential alternative method, and has become a technical focus competing in the field of medicine and health worldwide. In this article we introduce classification, manufacturing and application of organoids and OOC, and analyse the policies, research, development and industrial status quo in China and developed countries/ regions such as Europe and the United States. Basing on the conclusion, we insight the bottleneck problem of organoid technology, and look forward to the future development trend.

Key words: alternative method, organoid, organoids-on-chips, microphysiological systems

摘要： 类器官技术发展已有百年历史,但随着类器官芯片概念的提出,在芯片上构建人体器官微生理系统成为可能,使得类器官技术有望成为最具潜力的实验动物替代技术,也将成为全球医药健康领域争相布局的技术热点。本文介绍了类器官、类器官芯片的分类、制造与应用,以及类器官技术替代实验动物在医药研发中的应用进展。 通过分析国内外类器官技术政策、创新研发成果和产业现状等,透视类器官技术瓶颈问题,展望未来产业发展趋势。

关键词: 替代技术, 类器官, 类器官芯片, 微生理系统