关键词: 高糖饮食, 高脂饮食, 非酒精性脂肪肝, 大鼠模型

Abstract: Objective To study the difference between the rat nonalcoholic fatty liver models induced by high-fat diet and high-sucrose diet.Methods 90 SD rats were randomly divided into three groups of 30 rats each and were fed with nomal diet,high-fat diet and high-sucrose diet respectively.10 rats in each group were sacrificed at 4~(th),8~(th) and 12~(th) week.The level of ALT,AST,CHO,TG and HOMA-IR were investigated and the pathology of livers were observed by HE stain.Result The liver in both high-fat diet and high-sucrose diet group presented the pathology of steatosis and got more severe along with the time,especially the high-fat diet group.The rats' livers in high-fat group presented the pathology of steatohepatitis with higher serum levels of ALT and AST in the 12~(th) week.The CHO level in high-fat diet group and the TG level in high-sucrose group were significantly higher than control group.The HOMA-IR in high-fat group was significantly higher than high-sucrose group at 4~(th) and 8~(th) week,peraleled with the liver pathology.But at the 12~(th) week the HOMA-IR in high-fat group was lower than high-sucrose group significantly suggesting that other facters may also involve in the progression from simple steatosis to steatohepatitis.Conclusions High-fat and high-sucrose diet can induce nonalcoholic fatty liver rat model successfully and have different characteristics each.

Key words: Hight-fat diet, High-sucrose diet, Nonalcoholic fatty liver disease, Rat model