关键词: 高尿酸血症肾病, 尿酸, 高尿酸血症, 动物模型, 肾损伤

Abstract: Hyperuricemia nephropathy ( HN ) is a secondary kidney injury, mostly caused by the imbalance of uric acid production and excretion,resulting in hyperuricemia ( HUA) and thus triggering HN, whose main manifestations are renal inflammation, renal tubular injury, and renal interstitial fibrosis, which can easily lead to the functional damage of multiple organs if not intervened in a timely manner. As the prevalence of HN increases, the search for efficient and safe treatment options has become an urgent clinical task. However, at this stage, there is limited understanding of the mechanisms and therapeutic method of NH, and a well-recognized animal model has not yet been established. Therefore, in this paper, we systematically sorted out the commonly used model construction method from the aspects of animal selection, modeling method and effect evaluation, and sought to construct an efficient and stable animal model of HN.

Key words: hyperuricemicnephropathy, uric acid, hyperuricemia, animal models, kidney injury