Abstract: Intervertebral disc degeneration is a precondition for all kinds of spinal degenerative disease and pathological basis. It affects the health of the patients and reduces their quality of life, and at the same time brings burden to family economy and society. Although there are many studies on intervertebral disc degeneration at home and abroad, the causes of intervertebral disc degeneration are not very clear. It is important to study the mechanism and treatment of intervertebral disc degeneration by using related animal models. According to the current research status of animal models of intervertebral disc degeneration, the selection and modeling method of experimental animals were summarized.