关键词: 阿尔兹海默症, APP/PS1转基因小鼠, 中药

Abstract: Alzheimer's disease, is a central nervous system degenerative disease, the senile plaques and neurofibrillary tangles are its main characteristics. Patients with cognitive impairment, they can not take care of themselves. AD is a serious threat to the elder's health and longevity, the disease prevention and treatment has become a hot spot of research at home and abroad. In the field of experimental research on the prevention and treatment of AD, the transgenic mouse model of APP/PS1 is widely used, because it can better reflect the pathological features and clinical manifestations of patients with alzheimer's disease, and is a relatively ideal AD animal model. This paper reviews the past five years of traditional Chinese medicine effective component, Chinese medicine compound of APP ; PS1 transgenic mice AD advances in there search of the rapeutic effects oasto provide reference for subsequent research of prevention and treatment of AD.

Key words: Alzheimer's disease, APP /PSl transgenic mice, traditional Chinese medicine