关键词: 补骨脂, 肝毒性, 不同提取物

Abstract: Objective To study the toxicity of oral administration of rats in different extractions of psoralen, and provide a safe basis for its clinical application. Method One hundred and twelve SD rats were divided into 8 groups according to gender and body weight: control group, psoralen drug group, high and low dose group of osmotic lower osmosis, high osmium osmium permeation, In the low-dose group, the high-and low-dose group of psoralen osmosis drug slag (the dose of the crude drug group was 3 g/kg (raw dose), and the high and low doses of other drug-administered groups were 6 and 3 g/kg, respectively. (raw dose)), 14 in each group. After 4 weeks of continuous administration, after the end of the drug-administered period, the rats were fasted for 12 hours, and blood was taken for blood biochemical indicators. The organ was weighed and the organ coefficient was calculated and the MDA in the liver tissue was determined. Histopathological examination was performed. Result Compared with the control group, the liver organ coefficient, ALP and MDA of the psoralen crude drug group were significantly increased, the thymus organ coefficient and T-AOC were significantly decreased; the visceral osmosis liquid lower layer extract group was characterized by liver organ coefficient, T-AOC and ALT were significantly increased; the liver organ coefficient and MDA of the high-dose group of psoralen and sputum slag were significantly increased while the T-AOC value of female rats was significantly decreased, while the low-dose group of drug residue did not have liver or kidney. The toxicity index was significant; there was no significant difference in the upper layer of psoralen permeation. Conclusion The safety of the upper osmotic liquid of psoralen is better than that of the lower osmotic liquid of psoralen. However, based on the result of the determination of active ingredients, the lower layer of osmotic solution is more suitable for the drug site.

Key words: Psoralen, hepatotoxicity, different extractions