关键词: 大鼠细小病毒, ELISA, PCR, xTAG

Abstract: Rat parvovirus(RPV)is a DNA virus which contains variety of serotypes and can be divided into different strains. Both experimental rats and wild rodents can be naturally infected with RPV, but clinical disease and histological lesions have been observed different in rat infected with different strains. The RPV can have appreciable deleterious effects on research by contaminating rat tissues or organs and then result ing in changes in physiological and pharmacological parameters of rat. Therefore, it is critical to identify the infected experimental rat to minimize the impact on research. This paper aims to systematically expound the research of rat parvovirus detection technology, compare different method, and put forward problems and its prospects to provide reference of the experimental animal quality control.

Key words: rat parvovirus, ELISA, PCR, xTAG