关键词: 标准物质, 实验动物, 稳定性

Abstract: Objective To investigate the stability of 5 standard substances in order to obtain the storage condition and transportation condition of standard substance. Method On the basis of the national standard GB/T14927.1—2008, standard substances were prepared, stability test were carried on 4 temperatures(-20 ℃，4℃，room temperature and 37 ℃) and 8 time points (1 day、2 days、3 days、7 days、14 days、30 days、60 days and 90 days). Result 5 standard substances can be stably preserved during 90 days at 4 ℃ and -20 ℃. Catalase 2 standard substance can be preserved during 3 days at 37 ℃, the other 4 standard substances can be preserved only in 1 day at 37 ℃. At room temperature, malic enzyme 1, isocitric dehydrogenase 1 and catalase 2 can be preserved during 3 days. Alkaline phosphatase 1 can be preserved during 5 days. Peptidase 3 can be preserved in 14 days. Conclusion The preservation and transportation conditions of the standard substances must be controlled strictly during genetic quality evaluation of laboratory animals.

Key words: standard substance, laboratory animal, stability