关键词: 子宫内膜异位症, 盆腔粘连, 活血消异方, 腹膜, 转化生长因子-β1

Abstract: Objective To observe the therapeutic effect of Huoxue Xiaoyi Fang on pelvic adhesions and TGF-β1 in rats with endometriosis. Method To establish rat model of endometriosis pelvic adhesions by adopting the method of autologous transplantation that endometrial is transplanted on mesenteric.Rats were randomly divided into blank group, sham operation group,model group, Huoxue Xiaoyi Fang group and GnRH-α group.And then all rats were treated 28 days in a row.TGF-β1 protein and gene expression of rats’ adhesions peritoneal tissue or normal peritoneal tissue were detected. Result 1.The pelvic adhesions marks of model group, Huoxue Xiaoyi Fang group and GnRH-α group were all significantly higher than the sham operation group(P0.05).2.TGF-β1 protein and mRNA of model group were higher than the blank group and the sham operation group(P0.05). Conclusion TGF-β1 is involved in the occurrence and development of pelvic adhesions in endometriosis. Huoxue Xiaoyi Fang can improve the pelvic adhesions of endometriosis and inhibit the expression of TGF-β1 gene and protein in adhesion tissues.The curative effect of Huoxue Xiaoyi Fang is comparable to that of GnRH-α.

Key words: endometriosis, pelvic adhesions, Huoxue Xiaoyi Fang, peritoneum, TGF-β1