关键词: 啮齿类实验动物, 病理检测, 病变

Abstract: Objective Though detecting the pathological changes of laboratory rodents in Beijing, it provided a basis for the quality monitoring and improvement of laboratory rodents in Beijing. Method We collected hearts, livers, spleens, lungs, kidneys and intestinal tracts from 400 laboratory rodents in Beijing including 180 rats, 80 mice, 120 guinea pigs and 20 golden hamsters, and then made the paraffin sections stained with HE. The samples of the hepatocellular swelling were also stained by PAS and oil red O staining made from frozen sections, and observed under the microscope. Result The lesions of laboratory rodents mainly were hepatocellular swelling of mice, rats, guinea pigs and glycogen deposition in different degree, and liver fatty degeneration in guinea pigs; In addition, the mice and golden hamsters, especially hamsters, showed more liver necrosis and inflammatory cell infiltration. And the heart of mice and guinea pigs were hyperplasia, inflammatory cells infiltrated of kidney could be seen in mice. Conclusion The vast majority of laboratory rodents were pathologically diagnosed as healthy animals. But the feeding and management of some rodents still need to be strengthened, to provide a reliable and effective premise for the accuracy of the research experiment.

Key words: laboratory rodents, pathological diagnosis, pathological changes