关键词: <p>温郁金挥发油, 阿尔茨海默病, β-淀粉样蛋白, 认知能力 , </p>

Abstract: Abstract: Objective To investigate the effects of curcuma aromatica volatile oil on learning and memory in mice induced by β-amyloid( ( Aβ25 － 35 ) ． Method Sixty mice were divided into six groups randomly: sham group，model group，curcuma aromatica extract low dose group ( 0. 016 mL / kg) ，high dose group ( 0. 048 mL / kg) ，donepezil group ( 1. 30 mg / kg) and shenzhiling group ( 2. 6 mL / kg) ． β-Amyloid protein ( Aβ25 － 35 ) was infused into the hippocampal of mice． Drugs were administrated for 15 days． Y maze and Morris water maze was detected to evaluate the cognitive behavior． HE-staining was used to observe the neuron changes caused by curcuma aromatica volatile oil． Ｒesult Compared with the model group，curcuma aromatica volatile oil increase the alternation behavior significantly，decrease swimming escape latency and total distance，prolong the swimming distance percentage( P ＜ 0. 05 or P ＜ 0. 01) ; It also can improve the disorder，edema and other symptoms of hippocampus neurons，reduce the death of neurons． Conclusion Curcuma aromatica volatile oil can improve the effects of learning and memory in mice induced by β-amyloid( Aβ25 － 35 ) ．

Key words: <p>Curcuma aromatica volatile oil, Alzheimer's disease, β-amyloid, cognitive ability</p>