关键词: <, p>, 红景天苷, 压力超负荷, 心衰, 心电图<, /p>

Abstract: Abstract: Objective To explore the effect and mechanism of Salidroside in pressure-overload chronic heart failure rats． Method Totally 30 SD rats were randomly divided into sham operation group，heart failure group and Salidroside group，10 rats in each group． The HF group and SAL group were prepared by abdominal aorta constriction method，and S group only was worn line not constricted． SAL group was given subcutaneous injection from 12 weeks after operation by 60mg / kg·d in 30 days． The S group and HF group received the same dose of normal saline． After 30 days，two lead ECG parameters of limb a was measured and statistically analyzed． After the end of intervention，the rats were anesthetized，and abdominal aortic blood taken from the upper serum after centrifugation． Kit method was used to measure superoxide dismutase ( SOD) ，brain natriuretic peptide ( BNP) ，malondialdehyde ( MDA) ． Ｒesult Twelve weeks after operation，there was a decrease in heart rate，P amplitude and Ｒ amplitude comparing by those of the heart failure group ( P ＜ 0. 05 ) ． ECG showed a significant and ubiquitous J point depression ( P ＜ 0. 05) ，with ST segment notable elevation ( P ＜ 0. 05) ． SOD activity was significantly increased and BNP concentration was significantly decreased in SAL group compared to HF group ( P ＜ 0. 05) ． Conclusion These results show that Salidroside protects pressure-overload rat heart from failure possibly through reducing oxidation．

Key words: <p>salidroside, pressure overload, heart failure, electrocardiography</p>