关键词: <, p>, 鱼油, 高脂血症, 动物模型<, /p>

Abstract: Abstract: Objective To observe the therapeutic effect of different contents of EPA and DHA in fish oil on Hyperlipidemia of rats． Method 70 male SD rats were fed with high-fat diet for 10 days，then randomly divided into seven groups according to TC levels: disease model control group，Fenofibrate group ( 28 mg /kg) ，Seal Oil group ( 333 mg /kg) ，fish oil A group ( 167 mg /kg) ，fish oil C group ( 150 mg /kg) ，fish oil D group ( 183 mg /kg) ，fish oil E group ( 167 mg /kg) ，ten rats in each group，respectively． Ｒats were treated with high-fat diet and drugs for another 30 days． Then the levels of TC，TG，HDLC，LDLC，IL-2，IL-6，the ratio of liver weight and body weight，and histopathology changes of the liver were examined． Ｒesult Compared to the disease model group Fenofibrate can decrease the level of TC，TG，HDLC，LDLC， the degree of hepatic steatosis of Hyperlipidemia of rats，but increase the ratio of liver weight and body weight ( P ＜ 0. 05 or P ＜ 0. 01) ; Seal Oil decreased the level of TC，TG，HDLC，LDLC( P ＜ 0. 01) ; fish oil A and fish oil E decreased the level of TC，HDLC，LDLC( P ＜ 0. 01) ; fish oil D decreased the level of TC，TG，HDLC，LDLC( P ＜ 0. 01) ; fish oil C did not decrease the level of TC，TG，HDLC，LDLC( P ＞ 0. 05) ; all of them did not decrease the degree of hepatic steatosis of Hyperlipidemia of rats． Conclusion Fish oil A，fish oil D and fish oil E can improve Hyperlipidemia of rats model to a certain extent．

Key words: <p>fish oil, Hyperlipidemia, animal model</p>