关键词: <, p>, 病理学监测, 啮齿类实验动物, 质量评价<, /p>

Abstract: Abstract: Objective Assess the status of laboratory rodents by pathological diagnosis for offering some advices in standardized breeding to ensure accurate results of scientific research． Method Our laboratory collected the heart， liver，spleen， lung，kidney， large intestine and small intestine of animals，and put these tissues into 10% paraformaldehyde solution for fixation，and then prepared into two different sections for optical microscopy observation including all paraffin specimens stained with H． E． and the frozen sections stained with Oil Ｒed-O and PAS． Ｒesult Although the vast majority of laboratory rodents were microbiological，parasitological and genetical diagnosed as healthy animals every years． There still exists different degree of pathological damage in them． Liver cell swelling，slight lung lesion and protein cast of kidney were main lesions which might affect the health of laboratory rodents． Sometimes we also observed various lesions in heart，digestive tract and lymphoid organs．Conclusions These results further demonstrate that though the health levels of laboratory rodents meet the microbiological national standards，there is still a part of them in sub-health status． Pathological monitoring plays an irreplaceable role in assessing the quality of laboratory rodents． Ｒelevant regulatory departments should make the national and local pathological standardized policies for laboratory animals as soon as possible to improve the quality monitoring system of the experimental animals．

Key words: <p>pathological monitoring, laboratory rodents, quality assessment</p>