关键词: <, p>, 动物模型, 钙磷代谢, 慢性肾脏病<, /p>

Abstract: Abstract: Objective We produced the 5 /6 nephrectomy ( 5 /6 Nx) mice model of chronic kidney disease ( CKD) in order to observe FGF23，calcium phosphorus metabolism，and contribute to study the pathogenesis of CKDMBD．Method 28 C57 male mice were adapted for 1 week． Then the model group underwent unilateral renal ablation by 5 /6 Nx． Upper and low poles of the left kidney were cut． The right kidney was removed 1 week later．All the mice were executed at the 16th week． Blood，urine and kidney samples were collected． Then we detected FGF23，PTH，1，25( OH) 2D3，calcium，phosphorus and observed the renal histopathology． Result Comparedwith the sham group and the control group，the model group lost weight，had higher serum FGF23，PTH， phosphorus，urine output，urine protein and less 1， 25( OH) 2D3． Histopathology results found the kidney after 5 /6 Nx had proliferative mesangial matrix，increased collagen deposition，fibrosis and compensatory hypertrophy．Conclusion 5 /6 Nx mice had obvious characteristics of CKD-MBD，and is a good CKD-MBD model．

Key words: <p>animal model, calcium-phosphorus metabolism, chronic kidney disease</p>