关键词: 子宫直肠陷凹, 子宫内膜异位症, 动物模型, 移植, 产仔率

Abstract: Abstract: Objective To establish the uterine rectal pouch endometriosis model using female Wistar rat，and study the histological structure and pregnancy rates in those rats． Method Autologous uterus were transplanted into 40 female Wistar rats to establish the uterine rectal pouch endometriosis model，and 10 rats were treated as the shamoperated control． Male rats were permitted to approach the female models or controls 8 weeks after transplantation，and the farrowing rates and litter sizes were detected． The eutopic and ectopic endometrium were collected 15 weeks after transplantation for histological analysis． Ｒesult Based on the histological examination，development of the ectopic endometrium is different from that of the eutopic endometrium． The cell morphology of the ectopic endometrium changed from early proliferative phase to mid-secretory phase，but that of the eutopic endometrium changed from early proliferative phase to later secretory phase． The average litter size of model group was 6. 02，which was significant lower than the control group ( 8. 5) ( P ＜ 0. 01) or the sham operated group ( 8. 0) ( P ＜0. 01) ． Conclusion Development of the ectopic endometrium is not the same as that of the eutopic one． It makes the rat body environment abnormal，implantation of fertilized eggs difficult，and so reduces the reproductiveity．

Key words: uterine rectal pouch, endometriosis, animal model, transplantation, farrowing rate