关键词: 神经病理性疼痛, 脊神经结扎, 痛阈值

Abstract: Abstract:Objective To establish the animal model of L5 and L6 spinal nerve ligation (SNL) model of neuropathic pain rats. Method According to rat pain threshold, choose 90 SD rates of male surgery operation that the left L5 and L6 spinal nerves were exposed and tightly ligated with 6 -0 black silk, postoperative measured every other day after the left hind legs of rats mechanical pain threshold, compare the preoperative and postoperative reaction to pain stimulation change in rats. Result Postoperative the left hind legs of rats pain threshold gradually reduce, to 10 days to stabilize, and the preoperative have obvious difference (P≤0.01), The right hind legs of rats pain threshold were slightly elevated, remain in a stable level. Conclusion This research established SNL rats model of mechanical pain threshold changes significantly, good stability, high reliability, can be used as a kind of neuropathy pain model in rats.

Key words: neuropathic pain, spinal nerves ligation, pain threshold