关键词: 啮齿类实验动物, 病理学诊断, 脏器病变

Abstract: Abstract:Objective In May，2013，our lab has taken samples from 14 units to investigate the health status of Beijing laboratory rodents． Method The heart，liver，spleen，lung，kidney，large intestine and small intestine of animals were collected，and were put into 10% paraformaldehyde solution for fixation，and then two different sections were prepared for optical microscopy observation，including all paraffin specimens stained with H． E． and the frozen sections stained with Oil Ｒed O and PAS． Ｒesult Liver cell swelling，slight lung lesion and protein cast of kidney were main lesions which might affect the health of laboratory rodents． Conclusion The results showed that the vast majority of laboratory rodents were pathologically diagnosed as healthy animals． The result might be related to breeding and feeding environment and transport stress，and the improvement of management level can ameliorate the health status of laboratory rodents．

Key words: laboratory rodents, pathological diagnosis, organ diseases