关键词: :甲状腺素, 阴虚火旺证, 动物模型

Abstract: Abstract: Objective To observe the correlation between the exterior signs of mice model induced by thyroxine and hyperactivity of fire due to yin deficiency syndrome to provide reference for constructing hyperactivity of fire due to yin deficiency syndrome animal model． Method 48 standard weight mice were randomly divided into control group and three model groups，12 each group，male and female in half． Model groups were managed with thyroid tablet suspension of different doses ( 40 mg / kg，80 mg / kg and 160 mg / kg) respectively，whereas the control group with double-distilled water． The body weight，food intake，water intake，body temperature，spontaneous activity and heart rate were measured dynamically． Result As compared with the control group，mice in the model groups manifested slowly increased body weight，enhanced food intake and water intake，elevated body temperature，quicken heart rate and frequent spontaneous activity，which could simulate the major clinical characteristics of hyperactivity of fire due to yin deficiency syndrome，such as emaciation，voracious appetite，thirsty for water， internal heat，palpitation，impatience，et al． Among which，the exterior signs of female mice in high-dose model group were extremely notable compared with the control group ( P ＜ 0. 01 ) ． Conclusion The exterior signs induced by thyroxine can simulate the major clinical characteristics of hyperactivity of fire due to yin deficiency syndrome，the correlation between the exterior signs of female mice model induced by thyroxine i． g． 160 mg / kg / d for consecutive 14 days and hyperactivity of fire due to yin deficiency syndrome is more significantly．

Key words: Thyroid tablet, hyperactivity of fire due to yin deficiency syndrome, animal model