关键词: 突变基因, 无毛小鼠, 免疫器官

Abstract: Abstract: Objective To probe into the effects of hairless mutant gene on the structure and function of immune organs of hairless and haired mice． Method The observation of histological changes in immune organs and determinations of lymphocyte subset，proliferation of lymphocyte，and sIL-2R level in serum in hairless and haired mice，and comparison of the these indexes between hairless mice and haired mice were carried out． Result There were certain differences in structure and function of immune organs between hairless mice and haired mice． Conclusion It is suggested that the hairless mutant gene affects not only the hair structure but structure and function of immune organs，and that the gene in heterozygosity also exerts certain effect，indicating that it has certain codominance．

Key words:  mutant gene, hairless mice, immune organs