关键词: 免疫系统人源化小鼠, HIV 感染, 疟疾, 免疫缺陷小鼠, 胸腺

Abstract: Abstract: Animal models play a critical role in our understanding biomedicine sciences． The shortage of ideal animal models always limited our research in certain pathogen infection diseases such as HIV infection． Due to the species difference，some drugs and vaccines work well in certain animals but are not applicable for humans． Transplantation of fetal human thymus tissue，hematopoietic stem cells or immune cells into immune deficient mice will significantly establish human immunity． These humanized mouse models offered ideal models for studies on human immune system and immune-related diseases，and screening medicine and vaccines． The present paper will briefly introduce these humanized mouse models and their application．

Key words:  humanized mice with human immunity, HIV infection, malaria, immune deficient mice, thymus