关键词: 戊巴比妥钠, 水合氯醛, 麻醉, Wistar 大鼠

Abstract: Abstract: Objective To obtain new pentobarbital sodium solution by replacing general method of preparation，and investigate it's anesthetic effect on rats compared with general pentobarbital sodium and chloral hydrate． Method 120 rats were used in this study，which were randomly separated into 3 groups． Each group rats were respectively treated by general pentobarbital sodium，modified pentobarbital sodium and chloral hydrate with intraperitoneal injection，then observed the general state of rats，the acting time and anesthetic time were recorded，which were analyzed by statistics software． Result There were no significantly difference in acting time and anesthetic time between three groups，the variation of acting time and anesthetic time in modified pentobarbital sodium treated group was less than other two groups，and the successfully anesthetic number at first injection was significantly more than other two groups． Conclusion The study showed that the modified pentobarbital sodium could provide the stable anesthetic effect，which function was better than general pentobarbital sodium and chloral hydrate．

Key words: pentobarbital sodium, chloral hydrate, anesthesia, Wistar rat