关键词: 提取温度, 柴胡, 解热作用, 抗炎作用

Abstract: 0bjective To study the effect of the extraction temperature on the pharmacodynamic of Radix Bupleuri in decoction．Methods Through The experiments adopted the Lipopolysaccharide rat model of fever and the mouse pinna swelling induced by xylene，Then discussed the pharmacodynamic effect of Radix Bupleuri in decoction respectively at 60。C and I 00。C．Results First，Radix Bupleuriin decoction both have a certain antipyretic role at at 60。C and 100。C，Build the 4 h and 5 h temperature drop compared with model control group has significant difference(P<0．05)，The effects are almost same as aspirin，and antipyretic role lasted stability，butthe antipyretic actions of Radix Bupleurisolution is poorer got at 1 00℃．Second．Radix Bupleuriin decoction made by two producing methods both have better antiinflammatory action．mouse pinna swelling group were extremely significant difference compared with the control group(P<0．01)，the antiinflammatory action of Radix Bupleuriin decoction B extracted at 60℃are better than decoction A extracted at 100。C．but they are not significant． Conlusion The antipyretic role of Radix Bupleuri in decoction are better at 60。C，it is not significant effect of antiinflammatory action on extraction temperature．

Key words: extraction temperature, Radix Bupleuri, antipyretic role, antiinflammatory action