关键词: 化疗, 静脉炎, 氟尿嘧啶, 小鼠模型

Abstract: Abstract：0bjective To establish a stable and effective chemotherapy induced phlebitis(CIP)model in mice by intravenous injection of Fluorouracil．Methods Forty two KM mice were randomly divided into 6 treatment groups and 1 control group．The treatment groups were administrated with Fluorouracil at doses of 7．5 ms／mL，10．0 mg／mL，12．5 mg／mL，15．0 mS／mL，17．5 mg／mL，and 22．5 mg／mL respectively，and each mouse received Fluorouracil by injection of 0．4 mL volume into the left caudal vein．The control received the same volume of saline instead．All the mice were sacrificed at the third day after treatments．The degree of lesions was evaluated and pathological changes were examined under a microscope．Results The incidence rate of CIP showed a dependence on the dose of Fluorouracil．The mice dead when the dose was higher than 350 ms／kg(17．5 ms／mL group)．The incidence rate of CIP was 100％and the typical symptom of CIP was observed when the treatment groups received injection of Fluorouracil at 350mg／kg(1 5．0 ms／mL group)，with all mice surviving． But those changes were not observed in the control group．Conclusion The stable and effective mouse model of CIP can be established by caudal vein injection of Fluorouracil at doses from 300 mg／kg to 350 ms／kg．

Key words: Chemotherapy, Phlebitis, Fluorouracil, Mouse model