关键词: 转基因小鼠, 脂质代谢, CETP, LPL, 清道夫受体

Abstract: Transgenic animal model for diseases established to show diversified disease through the expression or excessive expression of gene. The lipid metabolizing is very a complex physiological process in human. During the gene relating lipid metabolizing, it includes the factors of causing arteriosclerosis formed and the factors of reducing arteriosclerosis attack. This paper described the transgenic animal model and its characters of gene of aplipoprotein (Apo) such as ApoE, ApoA, ApoB, ApoC, receptor gene sweeping receptor SR A, SR B and SR CD, gene of lipid metabolizing enzyme, gene of transprotein such as CETP, LPL etc. Those transgenic animal models play an important role in studying disease mechanism, drug screening, gene treatment and in producing the protein as drug using.

Key words: Transgenic mice, Lipid metabolism, CETP, LPL, Sweeping receptor