关键词: 实验动物, 北京地区, 质量检测, 微生物, 遗传, 抽检分析

Abstract: Objective　Analyze the monitoring results of microbiological and genetic quality of commonly used laboratory animals in Beijing from 2020 to 2022, so as to provide quality references for laboratory animal production units, users and testing institutions. Methods　In accordance with current valid national standards of the People’s Republic of China and local standards of Beijing Municipality, random inspections of laboratory animals in Beijing were conducted by the Beijing Office for Laboratory Animal Administration (Beijing Office for Human Genetic Resources Administration), with quality inspection reports issued based on the test results. According to the monitoring data, quality analyses were conducted on different grades of mice, rats, guinea pigs, hamsters, rabbits, dogs, monkeys, minipigs and laboratory fish in Beijing from 2020 to 2022. Results　During three years, a total of 3 723 batches of animals from 185 institutions were randomly inspected. The number of non-conforming batches in microbial detection was 26, 20 and 19 respectively. The main cause of non-conformity was positive pathogenic microorganisms (19 batches). All immunological indicators were qualified, and no genetic variation was found.Conclusion　From 2020 to 2022, the genetic quality of laboratory animals in Beijing was fully qualified, and the number of microbiologically non conforming batches decreased year by year, indicating a steady improvement in overall quality. The quality supervision of laboratory animals acts as a supervisory and regulatory measure, providing scientific guidance for practitioners to control and improve the quality of laboratory animals. Normalized quality sampling and supervision are of great significance in ensuring the scientificity and reliability of life science research, biomedical research and development, and other related work.

Key words:  laboratory animals, Beijing area, quality inspection, microorganisms, genetics, sampling inspection