关键词: 皮肤, 异种移植, 进展, 展望 

Abstract: Skin wounds are a significant burden on the healthcare system, and patients who survive severe burn injuries not only suffer significant long-term morbidity and disfigurement, but also develop a range of negative psychological effects that directly impact the combat effectiveness of the military. Xenografts can be used to treat skin wounds, providing new treatments for diseases such as cancer and organ damage. In this article, we summarize the current research status of skin xenografts in the treatment of burns, and focus on the current understanding of the immunological mechanisms of xenograft rejection. And we also summarized the research progress of pigs that have been bred for xenografts in the study of immune rejection to compensate for cross-species molecular incompatibility and protect the grafts from immune damage, in order to further provide guidance for the further development of pig skin for xenografts that is less likely to cause immune rejection in humans. 

Key words: skin, xenografts, progress, prospects