关键词: 阿尔茨海默症, 发病机制, 体内动物模型, 体外细胞模型

Abstract: Alzheimer’ s disease ( AD ) is a neurodegenerative disease characterized by cognitivedysfunction. As China’ s population aging becomes more and more serious, the proportion of peoplesuffering from AD is increasing, it is urgent to study its pathogenesis and establish appropriatepathological models to further study the prevention and treatment of AD. In this paper, in vitro and invivo AD models were reviewed, especially ten in vivo animal models (β-amyloid precursor protein (APP)transgenic model, D-galactose model, D-galactose combined with β-amyloid protein (Aβ) model and soon) and three in vitro models ( HT22 cell model, PC12 cell model and SH-SY5Y cell model) wereintroduced in detail. This study will provide AD reference and research ideas for further study and newdrug development for AD disease.

Key words: Alzheimer’ s disease, pathogenesis, in vivo animal model, in vitro cell model