关键词: 实验动物, 金黄色葡萄球菌, 感染, 分子分型

Abstract:  Staphylococcus aureus ( S. aureus) is a zoonotic opportunistic pathogen, which is must bemonitored and excluded from the barrier environment and often is a serious threat to the quality oflaboratory animals and the health of practitioners. It is critical to use accurate, sensitive, and rapidmethod of molecular typing to control the transmission of S. aureus in the laboratory animal barrierenvironment. The molecular method for typing S. aureus main including Staphylococcal cassettechromosome mec typing, Staphylococcal protein A typing, multilocus sequence typing, Pulsed field gelelectrophoresis typing, accessory gene regulator typing, and others. Understand the infection status ofStaphylococcus aureus in laboratory animals of barrier systems and comparation of the technicalcharacteristics and applications of different molecular typing method, which can provide a reference forthe detection and typing of Staphylococcus aureus of laboratory animal origin.

Key words: laboratory animal, Staphylococcus aureus, infection, molecular typing