关键词: 子痫前期, 动物造模, 病理改变

Abstract: Preeclampsia is the second leading cause of maternal mortality, pathophysiological research on the etiology of preeclampsia has long been a hot topic. About the in vivo research in the pre-eclampsia, mainly lies in how to build a animal model, appropriated animal model can be helpful for fully understanding the occurrence and development of the disease and its impact on the fetal litter, domestic and foreign researchers usually use animal models to study, modeling methods generally include biological modeling, surgical modeling, physical modeling, etc. , but a single modeling method still can not completely produce the same animal preeclampsia model as humans, but also need to choose a more appropriate modeling method according to the research purpose and expected results.

Key words: preeclampsia, animal modeling, pathological changes