Abstract:

Abstract:Osteoarthritis is a common and degenerative disease of the joints that lead to disability frequently, which seriously threat individual health and burden social public health. There is no effective radical cure for osteoarthritis clinically due to the complex and various pathogenic factors. Developing and establishing animal models of steoarthritis are necessary and significant for studying its pathogenesis, prevention and treatment. The modeling method of OA animal model mainly includes 3 categories: spontaneous modeling, induced modeling and transgenic modeling. In recent years, more and more transgenic OA models have been used in OA study. This review mainly comprehensively describes and analyzes the existing animal models of osteoarthritis, especially transgenic OA animal model, providing clues and ideas for the further development of more ideal animal models of osteoarthritis and OA related research.