Abstract: Abstract: Objective Novel coronavirus ( SARS-CoV-2) broke out in December 2019, which spread rapidly around the world, and seriously affected the normal social life. Due to the conservation of SARS-CoV-2 receptor angiotensin converting enzyme ( ACE2) in humans and animals, it is necessary to evaluate the susceptibility of domestic animals and laboratory animals. Methed Based on the amino acid sequence of ACE2, the evolutionary relationship of ACE2 in human, experimental animals and domestic animals were analyzed. According to the binding sites of RBD ( receptor binding domain) and ACE2, the variation between species was compared, and the susceptibility of different species to novel coronavirus was evaluated. Result The binding sites of SARS-CoV-2 and ACE2 were conservative in different species, and the binding sites of ACE2 receptor and SARS-CoV-2 RBD were completely consistent in human, monkey and hamster. Conclusion Based on the binding sites comparison and features of SARS-CoV-2 infected animals, monkey and hamster may be susceptible to novel coronavirus, and they may be preferred as SARS-CoV-2 infected animal models.