关键词: 绝经后大鼠, 骨质疏松, β连环蛋白, Dickkopf1蛋白

Abstract: Objective To explore the level of β-catenin in serum of postmenopausal osteoporosis rats and analyze its relationship with Dickkopf1 protein. Method Sixty-two postmenopausal osteoporosis rats were selected as the observation group , and 46 postmenopausal healthy rats were selected as the control group , and relevant analysis was performed .The relationship between β-catenin and related parameters was analyzed. Baseline data of the two groups of rats were compared . Logistic regression analysis was performed on the factors that may affect osteoporosis in postmenopausal rats. Result There was no significant correlation between serum β-catenin and nuclear factor kB receptor activating factor ligand levels in the two groups ( P>0. 05 ) . There was no significant correlation between serum β-catenin and Dickkopf1 protein levels in the control group ( P >0. 05 ) . Serum β-catenin was negatively correlated with Dickkopf1 protein in postmenopausal osteoporosis rats ( P 0. 05 ) . The β-catenin ( 23. 23 ±0. 07 ) pg/mL of the observation group was significantly lower than that of the control group, and the data were statistically significant (P<0. 05 ) . The nuclear factor kB receptor activating factor ligand ( 138. 24±96. 45 ) pmol/L and Dickkopf1 protein ( 182. 79±34. 81 ) pg/mL were significantly higher in the observation group than in the control group. The data were statistically significant (P<0.05 ) . High-level nuclear factor kB receptor activating factor ligand is an independent risk factor for osteoporosis in post menopausalrats and Dickkopf1 protein, and β-catenin is a protective factor for osteoporosis in postmenopausal rats ( P<0.05 ). Conclusion β-catenin and nuclear factor kB receptor activating factor ligands play an important role in the pathogenesis of osteoporosis. The levels of β-catenin and Dickkopf1 are related to the process of osteoporosis in postmenopausal rats , while the level of β-catenin is related to Dickkopf1 protein is positively correlated .

Key words: postmenopausal rats, Osteoporosis, β-catenin, Dickkopf1 protein