关键词: 人源化小鼠, 移植物抗宿主病, 白血病, 动物模型

Abstract: Animal models play an important role in the study of human disease pathogenesis and experimental study of pharmacology. Mice are currently the main experimental animals，However, it is different from the human background,and it cannot fully simulate the human immune system and disease state. Researchers can build humanized mouse models of the immune system and humanized mouse disease models by implanting human cells or tissues into immunodeficient mice. Humanized mice can obtain a mouse model with a high degree of humanization of the immune system by optimizing conditions such as the source of human hematopoietic stem cells and other conditions. At present, the humanized mouse model of GVHD and the humanized mouse model of leukemia have been used in the study of disease pathogenesis and the development of new clinical therapeutic drugs.

Key words: humanized mouse, Graft versus host disease, leukemia, animal models